September 12, 2016
Natural Products Insider

CURCUWIN CURCUMIN WITH ENHANCED ABSORPTION IMPROVES VASCULAR HEALTH IN HEALTHY SUBJECTS

CurcuWIN Curcumin with Enhanced Absorption Improves Vascular health in Healthy Subjects

A new groundbreaking study on CurcuWIN—a highly bioavailable form of curcumin extract—demonstrates efficacy in a healthy population for improving flow mediated dilation (FMD) at a low dose of 1000 mg CurcuWIN. Flow mediated dilation is a measure of endothelial function and a predictor of cardiovascular health. The study entitled “A Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double Blind Placebo Controlled Study” by Jonathan Oliver, et al., was published in the current issue of Journal of Nutrition and Metabolism, 2016.

“The inner lining of blood vessels is the endothelium and it plays a critical role in vascular health. The development and progression of cardiovascular disease depends on healthy endothelial function,” said Dr. Jonathan Oliver, PhD, CSCS*D, USAW, Assistant Professor, Texas Christian University. A major contributor to the development of cardiovascular disease is damage to blood vessels, specifically the vessel wall.  When this occurs, the vessel does not respond appropriately. Lifestyle behaviors and nutritional interventions that improve the function of the blood vessels lead to a reduced risk of cardiovascular disease.”

As the study name suggests, FloMeD measured the direct impact of a nutrient using flow mediated dilation on endothelial function and shows that supplementation with CurcuWIN impacts healthy circulation.

Sixty healthy, young adults aged 19 to 29, were enrolled in the randomized, double-blind, placebo-controlled study in which FMD was measured at baseline and after 8-weeks of supplementation with a placebo or either 250 mg or 1,000 mg of CurcuWIN, supplying 50 mg and 200 mg of curcumin, respectively.  The study demonstrated that 1,000 mg of CurcuWIN resulted in a significant improvement in FMD of approximately 3 percentage points (or 37% increase) compared to placebo.

“What’s really exciting about the FloMeD study is that CurcuWIN may potentially reduce CVD risk by 27-52% because every one percentage point increase in FMD potentially reduces cardiovascular risk by 9-17%,” stated Lynda Doyle, Sr. VP Global Marketing, OmniActive Health Technologies.

In a subset population of individuals with baseline FMD < 7% both doses resulted in a significant increase in FMD of 3.3 and 3.6 percentage points, respectively. Lower FMD values are considered at risk for CVD.

“CurcuWIN has been at the forefront of the highly-bioavailable curcumin market with our well-controlled clinical trial – the first study of its kind comparing standard and enhanced curcumin products,” said Doyle. “The study showed up to 46-times higher bioavailability compared to other enhanced forms and standard curcumin. We’re excited to show that this new study further supports how CurcuWIN’s greater bioavailability correlates to efficacy at a lower dose and demonstrates a unique benefit for vascular and heart health. CurcuWIN offers a great alternative to standard curcumin ingredients or when considering a bioavailable curcumin for your formulations.”

For more information on CurcuWIN, OmniActive’s ingredients or science, please contact Lynda Doyle at l.doyle@omniactives.com.

 About OmniActive Health Technologies Ltd

OmniActive Health Technologies (www.omniactives.com) offers a range of quality ingredients, which are innovative and scientifically validated for dietary supplementation, nutritional fortification, functional food/beverage, coloring, flavor enhancement and personal care applications. The company addresses complex challenges for customers in the dietary supplement, food and beverage space using technology-driven, sustainable solutions with application support within a global regulatory framework. Whether looking for a new ingredient to add to a finished product, or an ingredient solution to enhance an existing ingredient, you will find unmatched innovation at OmniActive.

Their Core products include carotenoids, plant extracts and specialty functional ingredients. OmniActive leverages international R&D strengths to deploy an array of state-of-the-art manufacturing technologies in extraction, purification, isolation and delivery of nutritional actives. The company’s manufacturing operations are located at multiple FDA inspected sites in India and are cGMP and HACCP system compliant.

 About The Journal of Nutrition and Metabolism

Journal of Nutrition and Metabolism is a peer-reviewed journal that publishes original research articles, review articles, and clinical studies in all areas of nutrition and metabolism.

 

References
J Nut Met. 2016.access at  http://dx.doi.org/10.1155/2016/1089653
Hypertension 2011: 57;363-369
Int J Cardiovasc Imag. 2010; 26: 631– 640
Circulation. 2004; 109 (23 suppl 1): 11127-32
 
CurcuWIN is a trademark of OmniActive Health Technologies Ltd.
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