OmniActive Health Technologies will present a poster on the study RS (Meso)-zeaxanthin Protects Retina From Oxidative Stress In A Rat Model at The Association of Research in Vision and Ophthalmology’s (ARVO) annual meeting, taking place from May 3rd-7th at the Colorado Convention Center, Denver, Colorado (US). The study was conducted by Vijaya Juturu Ph.D., F.A.C.N., Manager of Global Scientific and Clinical Affairs and Jayant Deshpande, Ph.D., CTO, OmniActive in collaboration with researchers from Firat University (Turkey).
RS-zeaxanthin along with lutein and RR-zeaxanthin are collectively known as the macular carotenoids. The study investigated the effects of RS-zeaxanthin’s ability to protect against chronic and cumulative eye damage and neutralize free radicals produced by oxidative stress. The hypothesis that RS-zeaxanthin administration reduces oxidative stress in the retina was tested in insulin resistant rodents induced by high-fat (HF) diet. Results suggest that RS-zeaxanthin administration significantly alleviated metabolic health markers, decreased selective gene proteins and improved antioxidant capacity in retinal tissues. Thiobarbituric acid reactive substances (TBARS) were reduced in serum and retinal tissue. No gross lesions, mortality or adverse events were observed. These observations suggest that RS-zeaxanthin may potentially be considered as an adjunct therapy to prevent diabetic retinopathy and to improve visual health in chronic conditions.
“What makes this study particularly exciting is that it further indicates RS-zeaxanthin’s tremendous potential as a relevant antioxidant in the maintenance of healthy vision,” stated Dr. Juturu. “Furthermore, it demonstrates that RS-zeaxanthin is a vital component of the complete macular carotenoid profile.”
Lutein and the two zeaxanthin isomers—RR-zeaxanthin and RS-zeaxanthin—are the only three carotenoids found in the eye, specifically in the macula. Each carotenoid plays a distinctive role from their highly selective positions in the eye. Their location in the macula is particularly specific: lutein is the deposited predominantly in the peripheral macula, RR-zeaxanthin in the mid-peripheral macula and RS-zeaxanthin at the very center of the macula—the focal point of visual function. Its central location and stronger antioxidant potential make RS-zeaxanthin critical in protecting the most at-risk tissue with the highest metabolic rate and light exposure, and it also provides the best protection for the lipid membrane.
“All three macular carotenoids—lutein as well as both zeaxanthin isomers (RR-zeaxanthin and RS-zeaxanthin)—are critical in eye health,” noted Dr. Deshpande. “This study further supports emerging science that supplementation with once-overlooked RS-zeaxanthin has a unique and important role in macular health, and highlights a promising opportunity for RS-zeaxanthin as one of the three key macular carotenoids in the expanding eye health supplement market.”
OmniActive offers the most comprehensive line of macular carotenoids. The study RS (Meso)-zeaxanthin Protects Retina From Oxidative Stress In A Rat Model is a valuable addition to the breath of science on the macular carotenoids as well as the expanding list of studies conducted by OmniActive—leaders in scientifically-validated, premium ingredients.
About ARVO annual meeting: With an impressive estimated 11,0000+ attendees for the 2015 meeting, ARVO brings together the world’s leading academicians, clinicians, researchers, students and trainees in the fields of vision research and eye science. As a globally-acclaimed forum for education and networking, ARVO was recognized as one of
the top 50 medical meetings by the Healthcare Convention & Exhibitors Association.
About ARVO: The Association for Research in Vision and Ophthalmology, Inc. (ARVO) was founded in 1928 in Washington, DC by a group of 73 ophthalmologists. The Association's membership today numbers about 12,000 from over 75 countries. Complementary to ARVO's mission, ARVO Foundation exists to provide ongoing support for innovative and novel vision research, particularly work with translational impact that fosters collaboration between clinicians and basic scientists.
About OmniActive Health Technologies
OmniActive Health Technologies (www.omniactives.com) offers a range of quality ingredients, which are innovative and scientifically validated for dietary supplementation, nutritional fortification, functional food/beverage, coloring, flavor enhancement and personal care applications. The company addresses complex challenges for customers in the dietary supplement, food and beverage space using technology-driven, sustainable solution with application support within a global regulatory framework. Whether looking for a new ingredient to add to a finished product, or an ingredient solution to enhance an existing ingredient, you will find unmatched innovation at OmniActive.
Core products include carotenoids, plant extracts and specialty functional ingredients. OmniActive leverages international R&D strengths to deploy an array of state of the art manufacturing technologies in extraction,purification, isolation and delivery of nutritional actives. The company’s manufacturing operations are located at multiple sites in India and are cGMP and HACCP system compliant.